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KMID : 0861020090240040149
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Korea Journal of Herbology
2009 Volume.24 No. 4 p.149 ~ p.157
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Effects of Cheunggyeongsamul-tang Extract on Longitudinal Bone Growth in Adolescent Female Rats
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Lee Jung-Hun
Lee Se-Na
Son Jae-Bong
Keum So-Hyun
Leem Kang-Hyun
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Abstract
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Objectives: This study was designed to investigate the effects of Cheunggyeongsamul-tang extract on the growth of longitudinal bone in adolescent female rats.
Methods: Longitudinal bone growth was measured by fluorescent microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate, the induction of local insulin-like growth factor-1 (IGF-1), IGF-1 receptor, bone morphogenetic protein-2 (BMP-2), BMPR-1A, indian hedgehog (IHH), and parathyroid hormone-related protein (PTH-rP) were measured.
Results: Cheunggyeongsamul-tang extract enhanced longitudinal bone growth and total height of the growth plate. Also, it promoted the induction of local IGF-1, BMP-2, IHH and PTH-rP of the growth plate.
Conclusions: This study shows that the Cheunggyeongsamul-tang extract effects longitudinal bone growth in adolescent rats and might be used for both stunted adolescents and inherent growth failure patients.
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KEYWORD
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Cheunggyeongsamul-tang, Longitudinal bone growth, Growth plate, Insulin-like growth factor-1, Bone morphogenetic protein-2. Indian hedgehog, Parathyroid hormone-related protein
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